on my desktop system i have ONLY alsa-lib and alsa-utils. and i really dislike pulseaudio and all that.
um, I'd say nope, skype works fine with basic alsa. works here on desktop system. minimal arch setup.
Just off the top of my head, i think perhaps OSS is going to cause as many issues initially (or even long-term) as perhaps alsa might. thing is, alsa allows latest skype and that's what I'm looking to use. can't rcall all the hell way back, though I'm alsa all the way with skype.
never any time to remember though I recall learning alsa somewhat took a while, then i went to OSS which was cool, then......BACK to alsa. OSS is great on BSD.
all the above said: I'm not a guru on this subject though my gut says go alsa and the latest linux skype bigtime.
whatever happens it's cool you're keeping the subject in our minds. great!!