I don't know whether this is considered crazy or not, but I just replaced Ubuntu with TC as my primary work/development OS!
I'm not a light user either - I'm a web application developer for a huge US corporation. I work with databases, Flex, AJAX, Java, Google App Engine, Coldfusion, Web Services, and more. I always have several servers running locally for testing, a big build of Eclipse as my IDE, and multiple instances of VirtualBox going.
My machine is reasonably powerful, with 4gb of ram, and tons of disk space. I have 2x24" monitors in TwinView. I'm running XFCE as my desktop manager - I'd slightly prefer LXDE but XFCE is the only DM that respects TwinView (I think, I know LXDE doesn't).
Besides some superficial quirks, everything's running like a dream with less bugginess and significantly more speed than my Ubuntu.
Just thought I'd share